American Jornal of Hematology
Fecha de publicación: 23 December 2017
DOI: https://doi.org/10.1002/ajh.25018
Autores:
Frank C. Kuo, Robert P. Hasserjian, Adam C. Seegmiller, Olga PozdnyakovaBackground: Recent work has identified distinct molecular subgroups of acute myeloid leukemia (AML) with implications for disease classification and prognosis. NPM1 is one of the most common recurrently mutated genes in AML. NPM1 mutations often co‐occur with FLT3‐ITDs and mutations in genes regulating DNA methylation, such as DNMT3A, TET2, and IDH1/2. It remains unclear whether these genetic alterations are associated with distinct immunophenotypic findings or affect prognosis.
Comentarios
Para dejar un comentario antes debes iniciar sesión:
¿No tienes una cuenta?
Regístrate a través de éste enlace.