A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence

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Cancer Cell

Fecha de publicación: 29 november 2018

DOI: https://doi.org/10.1016/j.ccell.2018.10.015

Autores: Bin Lu, Olaf Klingbeil, Yusuke Tarumoto, Tim D.D. Somerville, Yu-Han Huang, Yiliang Wei, Dorothy C. Wai, Jason K.K. Low.

Background: The Mixed Lineage Leukemia gene ( MLL) is altered in leukemia by chromosomal translocations to produce oncoproteins composed of the MLL N-terminus fused to the C-terminus of a partner protein.

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