Abnormal B Cell Development in Systemic Lupus Erythematosus

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Arthritis & Rheumatology

Fecha de publicación: 5 December 2017

DOI: https://doi.org/10.1002/art.40396

Autores: Sarah Karrar MBBS, BSc, Deborah S. Cunninghame Graham BSc, PhD

Background: Although the immunologic abnormalities in SLE are complex, numerous, and not fully understood, B cells have a central role in the development of the disease, from driving immune complex production to secretion of proinflammatory cytokines. Since SLE is an archetypal complex disease, the genetic association data reflect that complexity, with many variants, affecting several areas of the immune system 13, 14.