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Adult Paget’s disease of bone

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Rheumatology Oxford Journal
Published online:  1 December 2017

DOI: https://doi.org/10.1093/rheumatology/kew430

Stephen Paul Tuck, Robert Layfield, Julie Walker, Babitha Mekkayil, Roger Francis.

Objectives: Adult PD of bone is the second commonest metabolic bone condition after osteoporosis. The condition is characterized by increased bone cell activity, with bone-resorbing osteoclasts often larger and containing more nuclei than normal, and osteoblasts producing increased amounts of disorganized bone. This leads to expanded bone of poor quality possessing both sclerotic and lytic areas. PD of bone has a strong genetic element, with a family history being noted in 10–20% of cases.