American Journal of Hematology
First published: 11 December 2017
DOI: 10.1002/ajh.25003
Shaina M. Willen MD, Robyn Cohen MD, Mark Rodeghier PhD, Fenella Kirkham FRCPCH, MD research, Susan S. Redline MD, MPH, Carol Rosen MD, Jane Kirkby PhD, Michael R. DeBaun MD, MPH
Objective: The longitudinal pattern of lung function in children with sickle cell anemia (SCA) has shown a decrease in FEV1% predicted, a risk factor for death in adults with SCA, but predictors for this decline are poorly characterized. In a prospective longitudinal multi-center cohort of children with SCA, we tested the hypotheses that: FEV1% predicted declines over time; and SCA-specific characteristics and therapy predict this decline.
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