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Allogeneic hematopoietic stem cell transplantation from unrelated donors is associated with higher infection rates in children with acute lymphoblastic leukemia—A prospective international multicenter trial on behalf of the BFM‐SG and the EBMT‐PDWP

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Allogeneic hematopoietic stem cell transplantation from unrelated donors is associated with higher infection rates in children with acute lymphoblastic leukemia—A prospective international multicenter trial on behalf of the BFM‐SG and the EBMT‐PDWP

American Journal of Hematology

Fecha de publicación: 16 May 2019

DOI: https://doi.org/10.1002/ajh.25511

Autores: Herbert Pichler, Anita Lawitschka, Evgenia Glogova, Andre M. Willasch, Irene von Luettichau, Thomas Lehrnbecher, Susanne Matthes‐Martin, Peter Lang, Peter Bader, Karl W. Sykora, et al.

Background: Severe infections (SI) significantly impact on non‐relapse mortality after hematopoietic stem cell transplantation (HSCT). We assessed 432 children and adolescents with acute lymphoblastic leukemia (ALL) after total body irradiation based myeloablative HSCT within the multicenter ALL‐BFM‐SCT 2003 trial for SI grade 3 or higher according to common terminology criteria for adverse events.

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