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Altered DNA methylation in children born to mothers with rheumatoid arthritis during pregnancy

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Altered DNA methylation in children born to mothers with rheumatoid arthritis during pregnancy

Annals of the Rheumatic Diseases

Fecha de publicación: 29 May 2019

DOI: 10.1136/annrheumdis-2018-214930

Autores: Hilal Ince-Askan, Pooja R Mandaviya, Janine F Felix, Liesbeth Duijts, Joyce B van Meurs, Johanna M W Hazes, Radboud J E M Dolhain.

Background: The main objective of this study was to determine whether the DNA methylation profile of children born to mothers with rheumatoid arthritis (RA) is different from that of children born to mothers from the general population. In addition, we aimed to determine whether any differences in methylation are associated with maternal RA disease activity or medication use during pregnancy.

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