An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites

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An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites

Journal of Pharmacy and Pharmacology

Fecha de publicación: 3 May 2019

DOI: https://doi.org/10.1111/jphp.13098

Autores: Mohamed F. Attia, Nicolas Anton, Justine Wallyn, Ziad Omran Thierry F. Vandamme

Background: This review highlights both the physicochemical characteristics of the nanocarriers (NCs) and the physiological features of tumour microenvironment (TME) to outline what strategies undertaken to deliver the molecules of interest specifically to certain lesions. This review discusses these properties describing the convenient choice between passive and active targeting mechanisms with details, illustrated with examples of targeting agents up to preclinical research or clinical advances.

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