Rheumatology Oxford Journal
Volume 56, Issue 5, May 2017
Karina de Leeuw Laura Bungener Caroline Roozendaal Hendrika Bootsma Coen A. Stegeman
Abstract
Objective
Auto-antibodies directed to dsDNA (anti-dsDNA) are used in diagnosis and follow-up for SLE. However, multiple assays are used. The objective of this study was to determine the best-performing assays, especially in prediction of exacerbations.
Methods
Seven assays were compared during LN (n = 58). The two assays with the most frequent positive results during active nephritis were selected and tested in 152 SLE patients with quiescent disease, 40 with active disease and 214 disease controls. Furthermore, longitudinal samples of SLE patients with and without exacerbations were examined to determine the positive predictive value of an increase for an exacerbation.
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