Cancer-Specific Splicing Changes and the Potential for Splicing-Derived Neoantigens

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Cancer Cell

Fecha de publicación: 13 august 2018

DOI: 10.1016/j.ccell.2018.07.008

Autores: Luisa Escobar Hoyos, Omar Abdel-Wahab

Background: In this issue of Cancer Cell, Kahles et al. perform a comprehensive analysis of RNA splicing across cancer types and identify novel correlations between genetic alterations and splicing in cancer. In addition, they identify that tumor-specific splicing has the potential to generate a large new class of tumor-specific neoantigens.

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