Chronic neutrophilic leukemia: 2018 update on diagnosis, molecular genetics and management

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American Journal of Hematology

Fecha de publicación07 March 2018

DOI: https://doi.org/10.1002/ajh.24983

Autores: Michelle A. Elliott, Ayalew Tefferi

Background: Chronic neutrophilic leukemia (CNL) is a potentially aggressive myeloproliferative neoplasm, for which current WHO diagnostic criteria include leukocytosis of ≥ 25 x 109/L of which ≥ 80% are neutrophils, with < 10% circulating neutrophil precursors with blasts rarely observed. In addition, there is no dysplasia, nor clinical or molecular criteria for other myeloproliferative neoplasms.

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