Development of an enteric nanoparticle of marine sulfated polysaccharide propylene glycol alginate sodium sulfate for oral administration: formulation design, pharmacokinetics and efficacy

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Journal of Pharmacy and Pharmacology

Fecha de publicación: 12 March 2018


Autores: Pengli Li, Jiejie Hao, Haihua Li, Huashi Guan, Chunxia Li

Background: Propylene glycol alginate sodium sulfate (PSS) is poorly absorbed by oral administration due to its large molecular weight and slightly degradability in stomach acidic environment. Here, a novel enteric‐coated nano formulation of PSS (enteric PSS‐NP) was prepared to improve its bioavailability and efficacy.