Dysregulation of Mucosal Membrane Transporters and Drug-Metabolizing Enzymes in Ulcerative Colitis

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Journal of Pharmaceutical Sciences

Fecha de publicación: 26 september 2018

DOI: https://doi.org/10.1016/j.xphs.2018.09.024

Autores: Pascal Erdmann, Henrike Bruckmueller, Paul Martin, Diana Busch, Sierk Haenisch, Janett Müller, Anna Wiechowska-Kozlowska, Lars Ivo Partecke, Claus-Dieter Heidecke, Ingolf Cascorbi, Marek Drozdzik, Stefan Oswald.

Background: Intestinal transporters and metabolizing enzymes are the important factors of the intestinal absorption barrier. Because there is evidence that their expression and function may be affected during inflammatory conditions, we investigated gene expression, protein abundance, and regulation of relevant intestinal transporters and metabolizing enzymes in the intestinal mucosa of patients with ulcerative colitis (UC).

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