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Effects of Particle Surface Roughness on In-Die Flow and Tableting Behavior of Lactose

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Effects of Particle Surface Roughness on In-Die Flow and Tableting Behavior of Lactose

Journal of Pharmaceutical Sciences

Fecha de publicación: 2 May 2019

DOI: https://doi.org/10.1016/j.xphs.2019.04.028

Autores: Justin Yong, Soon Tay, Berlinda Wen, Ting Kok, Celine Valeria, Liew, Paul Wan Sia Heng

Background: Particle rearrangement takes place during the initial phase of tablet compaction. In this study, rough lactose particles were prepared by roller compaction, and their surface roughness modified by partial surface dissolution using a fluidized bed processor. Flow characteristics of the particles were determined using various flow methods, and their compaction characteristics studied using a compaction simulator with punches of different geometry and compaction pressure.

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