Eosinophilic gastroenteritis and other eosinophilic gut diseases distal to the oesophagus

The Lancet Gastroenterology & Hepatology

Fecha de publicación: Marzo 2018

DOI: https://doi.org/10.1016/S2468-1253(18)30005-0

Autores: Marjorie M Walker, Michael Potter, Nicholas J Talley

Background: Under normal physiological conditions, eosinophils are present throughout the gastrointestinal tract distal to the squamous oesophagus. Increases in their numbers signify primary and secondary eosinophilic conditions. The rare primary eosinophilic diseases eosinophilic gastroenteritis and eosinophilic colitis affect fewer than ten in 100 000 people, and are characterised by numerous mucosal eosinophils, distributed in sheets and sometimes extending from the mucosa into the submucosa. Pathogenesis of these diseases is poorly understood, but food allergies and intestinal dysbiosis have been implicated.

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