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Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies

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Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies

Cancer Cell

Fecha de publicación: 7 March 2019

DOI: https://doi.org/10.1016/j.ccell.2019.02.001

Autores: Yi-Zhou Jiang, Ding Ma, Chen Suo, Leming Shi, Wei Huang, Zhi-Ming Shao 

Background: We comprehensively analyzed clinical, genomic, and transcriptomic data of a cohort of 465 primary triple-negative breast cancer (TNBC). PIK3CA mutations and copy-number gains of chromosome 22q11 were more frequent in our Chinese cohort than in The Cancer Genome Atlas.

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