Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study

The Lancet Oncology

Published: 11 January 2018

DOI: https://doi.org/10.1016/S1470-2045(17)30891-4

Ellen R Copson, PhD*, Tom C Maishman, MSc*, Will J Tapper, PhD, Ramsey I Cutress, PhD, Stephanie Greville-Heygate, MB, Prof Douglas G Altman, PhD, Bryony Eccles, MD, Sue Gerty, BSc, Lorraine T Durcan, BSc, Prof Louise Jones, PhD, Prof D Gareth Evans, MD, Prof Alastair M Thompson, MD, Prof Paul Pharoah, PhD, Prof Douglas F Easton, PhD, Alison M Dunning, PhD, Prof Andrew Hanby, BM, Prof Sunil Lakhani, MD, Prof Ros Eeles, PhD, Prof Fiona J Gilbert, MB, Hisham Hamed, MD, Prof Shirley Hodgson, DM, Peter Simmonds, MB, Louise Stanton, MSc, Prof Diana M Eccles, MD

Background: Retrospective studies provide conflicting interpretations of the effect of inherited genetic factors on the prognosis of patients with breast cancer. The primary aim of this study was to determine the effect of a germline BRCA1 or BRCA2 mutation on breast cancer outcomes in patients with young-onset breast cancer.

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