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IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome

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IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome

Rheumatology Oxford Journal

Fecha de publicación: 20 July 2019

DOI: https://doi.org/10.1093/rheumatology/kez282

Autores: Shima Yasin, Ndate Fall, Rachel A Brown, Maggie Henderlight, Scott W Canna, Charlotte Girard-Guyonvarc’h, Cem Gabay, Alexei A Grom, Grant S Schulert.

Background: Systemic juvenile idiopathic arthritis (sJIA) is a childhood arthritis with features of autoinflammation and high risk of macrophage activation syndrome (MAS). IL-18 has been shown to have key roles in sJIA and MAS. We aimed to examine IL-18 levels in sJIA in relation to disease activity and history of MAS and other disease biomarkers namely S100 proteins and CXCL9.

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