Low‐flow ischaemia and reperfusion in rat hearts: energetic of stunning and cardioprotection of genistein

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Journal of Pharmacy and Pharmacology

Fecha de publicación: 21 june 2018

DOI: https://doi.org/10.1111/jphp.12945

Autores: Germán A. Colareda Alicia E. Consolini

Background: Low‐flow ischemia (LFI) is consequent to coronary disease and produces cardiac stunning during reperfusion (R). Energetic performance and mechanisms of Ca2+ handling during LFI/R are not known. Moreover, cardioprotection of the phytoestrogen genistein (Gen) remains to be demonstrated in LFI/R. The aim was to study the mechanisms of the stunning consequent to LFI/R and the effects of Gen on both sexes.

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