Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia

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Cancer Cell

Fecha de publicación: 10 december 2018

DOI: https://doi.org/10.1016/j.ccell.2018.11.002

Autores: Duohui Jing, Yizhou Huang, Xiaoyun Liu, Dominik Beck, John E. Pimanda, Richard B. Lock, et at.

Background: Glucocorticoids play a critical role in the treatment of lymphoid malignancies. While glucocorticoid efficacy can be largely attributed to lymphocyte-specific apoptosis, its molecular basis remains elusive.

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