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Multi-dimensional analysis identified rheumatoid arthritis-driving pathway in human T cell

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Multi-dimensional analysis identified rheumatoid arthritis-driving pathway in human T cell

Annals of the Rheumatic Diseases

Fecha de publicación: 5 June 2019

DOI: http://dx.doi.org/10.1136/annrheumdis-2018-214885

Autores: Masaru Takeshita, Katsuya Suzuki, Yasushi Kondo, Rimpei Morita, Yuumi Okuzono, Keiko Koga, Yoshiaki Kassai, Kanae Gamo, Maiko Takiguchi, Rina Kurisu, Hideyuki Mototani, et al.

Background: Rheumatoid arthritis (RA) is an autoimmune disease accompanied by lymphocyte infiltration into joint synovium. While T cells are considered to be important for its pathogenesis, the features that are the most relevant to disease and how they change after treatment remain unclear. The aim of this study was to clarify the characteristics of T cells in RA, comprehensively.

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