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Performance of two faecal immunochemical tests for the detection of advanced neoplasia at different positivity thresholds: a cross-sectional study of the Dutch national colorectal cancer screening programme

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Performance of two faecal immunochemical tests for the detection of advanced neoplasia at different positivity thresholds: a cross-sectional study of the Dutch national colorectal cancer screening programme

The Lancet Gastroenterology & Hepatology

Fecha de publicación: 26 november 2018

DOI: https://doi.org/10.1016/S2468-1253(18)30319-4

Autores: Clasine M de Klerk, MD., Els Wieten, MD., Iris Lansdorp-Vogelaar, PhD., Prof Patrick M Bossuyt, PhD., Manon CW Spaander, PhD., Prof Evelien Dekker, PhD ., et al.

Background: Faecal immunochemical tests (FITs) are recommended for colorectal cancer screening. Two frequently used FIT methods (FOB-Gold, Sentinel Diagnostics, Milan, Italy and OC-Sensor, Eiken Chemical, Tokyo, Japan) perform similarly in detecting advanced neoplasia (ie, colorectal cancer and advanced adenoma) at a fixed positivity cutoff for faecal haemoglobin concentration.

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