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Performing routine follow-up biopsy 1 year after diagnosis does not affect long-term outcomes in coeliac disease

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Performing routine follow-up biopsy 1 year after diagnosis does not affect long-term outcomes in coeliac disease

Alimentary Pharmacology & Therapeutics
Volume 45, Issue 11, June 2017, Pages 1459–1468

H. Pekki,
 K. Kurppa,
 


M. Mäki,
 


H. Huhtala,
 


K. Laurila,
 


T. Ilus, K. Kaukinen

Abstract

Background

A repeat biopsy is recommended, but often omitted in coeliac disease patients on a gluten-free diet. The effect of performing or not performing repeat biopsies is currently unknown.

Aim

To identify factors associated with and the significance of lacking biopsy for long-term outcome. Predictors and the importance of incomplete histological recovery after 1 year was investigated in re-biopsied patients.

Methods

A total of 760 patients participated in a nationwide follow-up study. Medical data were gathered via interviews and patient records, and blood samples were drawn for serology. Current symptoms and well-being were assessed by validated PGWB, SF-36 and GSRS questionnaires.

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