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Plasmablasts With a Mucosal Phenotype Contribute to Plasmacytosis in Systemic Lupus Erythematosus

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Plasmablasts With a Mucosal Phenotype Contribute to Plasmacytosis in Systemic Lupus Erythematosus

Arthritis & Rheumatology
First published: 

DOI: 
10.1002/art.40181

Henrik E. Mei, Stefanie Hahne, Andreas Redlin, Bimba F. Hoyer, Kaiyin Wu, Lisa Baganz, Anna R. Lisney, Tobias Alexander, Birgit Rudolph and Thomas Dörner

Objective: To analyze the composition of known plasmacytosis in systemic lupus erythematosus (SLE) to obtain further insight into the nature of underlying mechanisms.

Methods: Plasmablasts from patients with active SLE, patients with inactive/treated SLE, and healthy controls were characterized by flow cytometry, enzyme-linked immunospot assay, and Transwell migration assays and compared to vaccination-induced plasmablasts. Serum cytokine levels were analyzed by Luminex assay, and histologic analysis of kidney biopsy specimens was performed.

 

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