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Polypharmacy is associated with treatment response and serious adverse events: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

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Polypharmacy is associated with treatment response and serious adverse events: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

Rheumatology Oxford Journal

Fecha de publicación: 14 April 2019

DOI: https://doi.org/10.1093/rheumatology/kez037

Autores: Katie Bechman, Benjamin D Clarke, Andrew I Rutherford, Mark Yates, Elena Nikiphorou, Mariam Molokhia, Sam Norton, Andrew P Cope, Kimme L Hyrich, James B Galloway.

Background: The BSRBR-RA is a prospective observational cohort study of biologic therapy starters and a DMARD comparator arm. A logistic regression model was used to calculate the odds of a EULAR ‘good response’ after 12 months of biologic therapy by medication count. Cox proportional hazards models were used to identify risk of SAEs. The utility of the models were compared with the Rheumatic Disease Comorbidity Index using Receiver Operator Characteristic and Harrell’s C statistic.

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