European Journal of Hematology
First published: 2 June 2017
Yong Yang, Jisheng Lin, Zhao Ma, Jinjun Li, Dong Li, Bingqiang Wang, Qi Fei
Objectives: The etiology of multiple myeloma (MM) is unknown and it remains incurable. We sought to elucidate the mechanisms underlying miRNAs involvement in MM pathogenesis.
Methods: Public mRNA and miRNA expression datasets for MM were collected from the Gene Expression Omnibus database. By integrated bioinformatics analysis, the expression signatures were identified and the miRNA-mRNA interaction network was constructed. The potential functions of target genes were then explored by functional enrichment…