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Prevalence and Characteristics of Persistent Clonal T‐LGL Expansions in Rheumatoid Arthritis: a Comprehensive Analysis of 529 Patients

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Prevalence and Characteristics of Persistent Clonal T‐LGL Expansions in Rheumatoid Arthritis: a Comprehensive Analysis of 529 Patients
Arthritis & Rheumatology
 

Fecha de publicación: 25 June 2018

DOI: https://doi.org/10.1002/art.40654

Autores: Eva C. Schwaneck, Regina Renner, Lara Junker, Hermann Einsele, Ottar Gadeholt, Eva Geissinger, Stefan Kleinert, Michael Gernert, Hans‐Peter Tony, Marc Schmalzing.

Background: Up to one third of patients with T‐cell large granular lymphocyte leukemia (T‐LGL‐leukemia) display symptoms of rheumatoid arthritis (RA). In Crohn’s disease and in psoriasis treatment with TNFα‐inhibitors is associated with hepatosplenic γδT‐cell‐lymphoma and with clonal expansion of γδT‐cells, respectively. 

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