Tandem Duplications May Supply the Missing Genetic Alterations in Many Triple-Negative Breast and Gynecological Cancers

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Cancer Cell

Fecha de publicación: July 12, 2018

DOI: https://doi.org/10.1016/j.ccell.2018.07.011

Autores: Manisha Rao, Scott Powers.

Background: In this issue of Cancer Cell, Menghi et al. show that tandem duplications (TDs) are a common genetic feature of gynecological and triple-negative breast cancers. They also provide evidence that these TDs generate genetic alterations driving these cancers, which, if substantiated, will fundamentally change our understanding of their oncogenesis.