A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia

Cancer Cell

First published:  8 January 2018

DOI: http://dx.doi.org/10.1016/j.ccell.2017.12.002

Yali Xu, Joseph P. Milazzo, Tim D.D. Somerville, Yusuke Tarumoto, Yu-Han Huang, Elizabeth L. Ostrander, John E. Wilkinson, Grant A. Challen, Christopher R. Vakoc

Background: Targeting of general coactivators is an emerging strategy to interfere with oncogenic transcription factors (TFs). However, coactivator perturbations often lead to pleiotropic effects by influencing numerous TFs. Here we identify TAF12, a subunit of TFIID and SAGA coactivator complexes, as a selective requirement for acute myeloid leukemia (AML) progression. 

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