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The Evolving Landscape for Complement Therapeutics in Rheumatic and Autoimmune Diseases

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The Evolving Landscape for Complement Therapeutics in Rheumatic and Autoimmune Diseases

Arthritis & Rheumatology

Published online: 17 October 2017

DOI: 10.1002/art.40219

Joshua M. Thurman MD, Ashley Frazer-Abel PhD, V. Michael Holers MD

Objectives: The complement system is increasingly understood to play major roles in the pathogenesis of human inflammatory and autoimmune diseases. Because of this situation, there are rapidly expanding commercial efforts to develop novel complement inhibitors and effector pathway–modulating drugs. This review provides insights into the evolving understanding of the complement system components, mechanisms of activation within and across the 3 pathways (classical, alternative, and lectin), how the pathways are normally controlled and then dysregulated in target tissues, and what diseases are known to be, in large part, complement-dependent through the successful development and approval of complement therapeutics in patients.

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