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The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review

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The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review

Journal of Pharmacy and Pharmacology

Fecha de publicación: 10 April 2018

DOI: https://doi.org/10.1111/jphp.12912

Autores: Laura J. Henze, Niklas J. Koehl, Joseph P. O’Shea, Edmund S. Kostewicz, René Holm, Brendan T. Griffin

Background: In pharmaceutical drug development, preclinical tests in animal models are essential to demonstrate whether the new drug is orally bioavailable and to gain a first insight into in vivo pharmacokinetic parameters that can subsequently be used to predict human values. 

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