The role of fat and inflammation in the pathogenesis and management of osteoarthritis

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Rheumatology Oxford Journal

Fecha de publicación: 09 February 2018


Autores: Hema Urban, Christopher B Little

Background: OA is a complex disease involving mechanical, metabolic and inflammatory contributions to its aetiology. A key risk factor, obesity, is becoming an increasing focus of research due to its multiple potential impacts on OA incidence, progression and symptom severity. An increased load due to an increase in body mass has been well established as a mechanical contribution to the pathophysiology of OA. However, evidence of obesity-linked to OA in non-weight-bearing joints has implicated the biological role of adipose inflammation and metabolic abnormalities in OA.