The Lancet Oncology
Published: 07 April 2017
Smita S Chandran, PhD, Robert P T Somerville, PhD, James C Yang, MD, Richard M Sherry, MD, Christopher A Klebanoff, MD, Stephanie L Goff, MD, John R Wunderlich, MD, David N Danforth, MD, Daniel Zlott, PharmD, Biman C Paria, PhD, Arvind C Sabesan, MD, Abhishek K Srivastava, PhD, Liqiang Xi, PhD, Trinh H Pham, MS, Mark Raffeld, MD, Donald E White, MS, Mary Ann Toomey, BSN, Steven A Rosenberg, MD, Dr Udai S Kammula, MD
Background: Uveal melanoma is a rare tumour with no established treatments once metastases develop. Although a variety of immune-based therapies have shown efficacy in metastatic cutaneous melanoma, their use in ocular variants has been disappointing. Recently, adoptive T-cell therapy has shown salvage responses in multiple refractory solid tumours. Thus, we sought to determine if adoptive transfer of autologous tumour-infiltrating lymphocytes (TILs) could mediate regression of metastatic uveal melanoma.