Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin-O-glucuronide in HeLa1A1 cells

Journal of Pharmacy and Pharmacology

Fecha de publicación: 9 de julio de 2020

Autores: Yang Li, Chunxia Xu, Jinjin Xu, Zifei Qin, Shishi Li, Liufang Hu, Zhihong Yao, Frank J. Gonzalez, Xinsheng Yao

DOI: https://doi.org/10.1111/jphp.13324

Background: Bavachin is a bioactive natural flavonoid with oestrogen-like activity. Here, we aimed to investigate its metabolic and disposal fates involving in CYPs, UGTs and efflux transporters.

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