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Reduced global cerebral oxygen metabolic rate in sickle cell disease and chronic anemias

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Reduced global cerebral oxygen metabolic rate in sickle cell disease and chronic anemias

American Journal of Hematology

Fecha de publicación: 23 de abril de 2021

Autores: Chau Vu, Adam Bush, Soyoung Choi, Matthew Borzage, Xin Miao, Aart J. Nederveen, Thomas D. Coates, John C. Wood

DOI: https://doi.org/10.1002/ajh.26203

Background: Anemia is the most common blood disorder in the world. In patients with chronic anemia, such as sickle cell disease or major thalassemia, cerebral blood flow increases to compensate for decreased oxygen content. However, the effects of chronic anemia on oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) are less well understood. In this study, we examined 47 sickle-cell anemia subjects (age 21.7 ± 7.1, female 45%), 27 non-sickle anemic subjects (age 25.0 ± 10.4, female 52%) and 44 healthy controls (age 26.4 ± 10.6, female 71%) using MRI metrics of brain oxygenation and flow.

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