A comparative study on pharmacokinetics and tissue distribution of 5‐hydroxy‐4‐methoxycanthin‐6‐one and its metabolite in normal and dextran sodium sulfate‐induced colitis rats by HPLC‐MS/MS

Journal of Pharmacy and Pharmacology

Fecha de publicación: 3 de Mayo de 2020

DOI: https://doi.org/10.1111/jphp.13285

Autores: Fangle Liu, Qiuyu Zhang, Chaozhan Lin, Yufeng Yao, Meiqi Wang, Changhui Liu, Chenchen Zhu

Abstract

Objective: This study aimed to investigate the existing form of 5‐hydroxy‐4‐methoxycanthin‐6‐one (PQ‐A) in vivo after oral administration and the effects on its pharmacokinetics and tissue distribution by colitis.