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Adenosine Metabolism: Emerging Concepts for Cancer Therapy

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Adenosine Metabolism: Emerging Concepts for Cancer Therapy

Cancer Cell

Fecha de publicación: 9 December 2019

DOI: https://doi.org/10.1016/j.ccell.2019.10.007

Autores: Detlev Boison, Gennady G. Yegutkin

Background: Adenosine is a key metabolic and immune-checkpoint regulator implicated in the tumor escape from the host immune system. Major gaps in knowledge that impede the development of effective adenosine-based therapeutics include: lack of consideration of redundant pathways controlling ATP and adenosine levels; lack of distinction between receptor-dependent and -independent effects of adenosine, and focus on extracellular adenosine without consideration of intracellular metabolism and compartmentalization.

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