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Adolescent and young adult acute lymphoblastic leukemia. Final results of the phase II pediatric‐like GIMEMA LAL‐1308 trial

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Adolescent and young adult acute lymphoblastic leukemia. Final results of the phase II pediatric‐like GIMEMA LAL‐1308 trial

American Journal of Hematology

Fecha de publicación: 7 de diciembre de 2020

DOI: https://doi.org/10.1002/ajh.26066

Autores: Anna Maria Testi, Martina Canichella, Antonella Vitale, Alfonso Piciocchi, Anna Guarini, Irene Della Starza, Marzia Cavalli, Maria Stefania De Propris, Monica Messina, Loredana Elia, Maria Luisa Moleti, Bruno Martino, Mario Luppi, Marianna D’Aloisio, Anna Candoni, Valentino Conter, Paola Fazi, Marco Vignetti, Sabina Chiaretti, Roberto Foà

Background: Adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) represent a unique patient population with specific characteristics and needs. Growing evidences suggest that pediatric‐inspired approaches improve the outcome in AYA. These results prompted the design of a pediatric AIEOP‐BFM ALL 2000‐based regimen ‐ the GIMEMA LAL‐1308 protocol ‐ for newly diagnosed AYA (range 18‐35 years) with Philadelphia negative (Ph‐) ALL. The protocol included minimal residual disease (MRD) analysis at two different time‐points (TP), that is, at the end of induction IA and consolidation IB, and a modulation in post‐consolidation intensity according to MRD. Seventy‐six patients were eligible between September 2010 and October 2014.

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