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Association of Agricultural, Occupational, and Military Inhalants With Autoantibodies and Disease Features in US Veterans With Rheumatoid Arthritis

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Association of Agricultural, Occupational, and Military Inhalants With Autoantibodies and Disease Features in US Veterans With Rheumatoid Arthritis

Arthritis & Rheumatology

Fecha de publicación: 15 de octubre de 2020

DOI: https://doi.org/10.1002/art.41559

Autores: Ariadne V. Ebel, Gabrielle Lutt, Jill A. Poole, Geoffrey M. Thiele, Joshua F. Baker, Grant W. Cannon, Angelo Gaffo, Gail S. Kerr, Andreas Reimold, Pascale Schwab, Namrata Singh, J. Steuart Richards, Dana P. Ascherman, Ted R. Mikuls, Bryant R. England

Background: To determine the association of inhalant exposures with rheumatoid arthritis (RA)–related autoantibodies and severity in US veterans. Methods: Participants in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were mailed surveys assessing occupational, agricultural, and military inhalant exposures. Demographic characteristics, disease activity, functional status, and extraarticular features were obtained from the VARA registry, while HLA–DRB1 shared epitope (SE) status, anti–cyclic citrullinated peptide (anti‐CCP) antibodies, and rheumatoid factor (RF) were measured using banked DNA/serum from enrollment. Associations between inhalant exposures and RA‐related factors (autoantibodies, severity, and extraarticular features) were assessed using multivariable linear and logistic regression models adjusted for age, sex, race, and tobacco use and stratified by SE status. Adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.

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