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Association of donor IFNL4 genotype and non-relapse mortality after unrelated donor myeloablative haematopoietic stem-cell transplantation for acute leukaemia: a retrospective cohort study

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Association of donor IFNL4 genotype and non-relapse mortality after unrelated donor myeloablative haematopoietic stem-cell transplantation for acute leukaemia: a retrospective cohort study

The Lancet Haematology

Fecha de publicación: October, 2020

DOI: https://doi.org/10.1016/S2352-3026(20)30294-5

Autores: Shahinaz M Gadalla, PhD , Youjin Wang, PhD, Tao Wang, PhD, Olusegun O Onabajo, PhD, A Rouf Banday, PhD, Adeola Obajemu, MS, Ezgi Karaesman, MS, Prof Lara Sucheston-Campbell, PhD, Prof Theresa Hahn, PhD, Jennifer A Sees, MPH, Stephen R Spellman, MBS. Prof Stephanie J Lee, MD, Hormuzd A Katki, PhD, Ludmila Prokunina-Olsson, PhD

Background: The interferon lambda 4 gene ( IFNL4) regulates immune responses by controlling the production of IFNλ4, a type III interferon. We hypothesised that IFNλ4 could play a role in infection clearance or alloreactivity in patients with acute leukaemia who received a myeloablative 10/10 HLA-matched haematopoietic stem-cell transplantation (HSCT). Therefore, we aimed to assess the association between recipient and donor IFNL4 genotype with post-HSCT survival outcomes in patients with acute leukaemia.

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