Augmented Th17 Differentiation Leads to Cutaneous and Synovio‐Entheseal Inflammation in a Novel Model of Psoriatic Arthritis

Fecha de publicación: 13 February 2018

DOI: https://doi.org/10.1002/art.40447

Autores: Lu Yang, Melania H. Fanok PhD, Aranzazu Mediero‐Munoz PhD, Laura K. Fogli PhD, Carmen Corciulo PhD, Shahla Abdollahi PhD, Bruce N. Cronstein MD …

Background: Methods we characterized a novel murine model of Th17‐driven cutaneous and synovio‐entheseal disease directed by T cell–specific expression of a hyperactive Stat3 allele. By crossing R26Stat3C^stopfl/fl CD4Cre mice onto an interleukin‐22 (IL‐22)–knockout background or treating the mice with a neutralizing antibody against IL‐17, we interrogated how these Th17 cytokines could contribute to the pathogenesis of PsA.