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Benefit of biologics initiation in moderate versus severe rheumatoid arthritis: evidence from a United States registry

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Benefit of biologics initiation in moderate versus severe rheumatoid arthritis: evidence from a United States registry

Rheumatology Oxford Journal
Published:
08 March 2017
DOI: https://doi.org/10.1093/rheumatology/kex042

Arthur Kavanaugh Edward Keystone Jeffrey D. Greenberg George W. Reed Jenny M. Griffith Alan W. Friedman Katherine C. Saunders Arijit Ganguli

Objectives: To compare clinical outcomes and treatment patterns among patients with moderate vs severe RA following biologic DMARD initiation.

Methods: Biologics-naive patients with moderate to severe RA [Clinical Disease Activity Index (CDAI) >10] who initiated a biologic DMARD were selected from the Corrona registry (2001–13). CDAI, functional status [modified HAQ (mHAQ)] and patterns of drug use were compared at 1 and 2 years post-initiation between patients with moderate…

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