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BRCA Mutation Association with Recurrence Score and Discordance in a Large Oncotype Database

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BRCA Mutation Association with Recurrence Score and Discordance in a Large Oncotype Database

Oncology: International Journal of Cancer Research and Treatment

Fecha de publicación: April 2020

DOI: https://doi.org/10.1159/000504965

Autores: Blanter J., Zimmerman B., Tharakan S., Ru M., Cascetta K., Tiersten A.b

Background: The Oncotype DX Breast Cancer Assay is a 21-gene assay used to predict the likelihood of distant recurrence and the benefit of chemotherapy in patients with node-negative, tamoxifen-treated breast cancer. Prior studies demonstrated 7–19% discordance, or a difference between the recurrence score (RS) and tumor grade (TG) in breast cancer patients. BRCA mutated tumors (BRCA+) have been shown to be associated with higher RS as compared to BRCA-negative patients (BRCA–).

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