CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

Cancer Cell

Fecha de publicación: 26 December 2019

DOI: https://doi.org/10.1016/j.ccell.2019.11.003

Autores: Hua Zhang, Camilla L. Christensen, Ruben Dries, George Miller
Nathanael S. Gray, Kwok-Kin Wong

Background: Cyclin-dependent kinase 7 (CDK7) is a central regulator of the cell cycle and gene transcription. However, little is known about its impact on genomic instability and cancer immunity. Using a selective CDK7 inhibitor, YKL-5-124, we demonstrated that CDK7 inhibition predominately disrupts cell-cycle progression and induces DNA replication stress and genome instability in small cell lung cancer (SCLC) while simultaneously triggering immune-response signaling.

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