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Chronic opioid use is associated with early biologic discontinuation in inflammatory bowel disease

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Chronic opioid use is associated with early biologic discontinuation in inflammatory bowel disease

Alimentary Pharmacology & Therapeutics

Fecha de publicación: 26 de enero de 2021

DOI: https://doi.org/10.1111/apt.16269

Autores: Christian Rhudy, Courtney L. Perry, Michael Singleton, Jeffery Talbert, Terrence A. Barrett

Background: Chronic opioid use is associated with poorer clinical outcomes in inflammatory bowel disease. Aims: To investigate an association between chronic opioid use and persistence with biologic agents in management of inflammatory bowel disease. Methods: A total of 16 624 patients diagnosed with inflammatory bowel disease and receiving a first‐time biologic prescription from 2011 to 2016 were identified retrospectively from the Truven MarketScan Database. A cohort of 1768 patients were identified as chronic opioid users utilising outpatient prescription claims.

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