Circular RNA TMEM87A promotes cell proliferation and metastasis of gastric cancer by elevating ULK1 via sponging miR-142-5p

Journal of Gastroenterology

Fecha de publicación: 6 de noviembre de 2020

DOI: https://doi.org/10.1007/s00535-020-01744-1

Autores: Haixiao Wang, Guangli Sun, Penghui Xu, Jialun Lv, Xing Zhang, Lu Zhang, Sen Wang, Jiacheng Cao, Yiwen Xia, Zhe Xuan, Bowen Li, Xiaoxu Huang, Tianlu Jiang, Lang Fang & Zekuan Xu 

Background: Circular RNAs (circRNAs) act as vital regulators of gene expression in a variety of cancers. However, the role of circRNAs in gastric cancer (GC) remains largely unexplored. Herein, we identified that circTMEM87A sponges miR-142-5p to promote GC progression through up-regulating ULK1 expression.