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Clinical importance of IL-22 cascade in IBD

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Clinical importance of IL-22 cascade in IBD

Journal of Gastroenterology

Fecha de publicación: 26 October 2017

DOI: https://doi.org/10.1007/s00535-017-1401-7

Autores: Atsushi Mizoguchi, Arisa Yano, Hidetomo Himuro, Yui Ezaki, Takayuki Sadanaga, Emiko Mizoguchi.

Background: IL-22 is a relatively new cytokine that is characterized by several unique biological properties. In the intestines, the effect of IL-22 is restricted mainly to non-lymphoid cells such as epithelial cells. Interestingly, the expression pattern and major cellular source of IL-22 have distinct difference between large and small intestines. 

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