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Comprehensive Profiling of the Rheumatoid Arthritis Antibody Repertoire

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Comprehensive Profiling of the Rheumatoid Arthritis Antibody Repertoire

Arthritis & Rheumatology

Fecha de publicación: 26 August 2020

DOI: https://doi.org/10.1002/art.41089

Autores: Ken C. Lo, Eric Sullivan, Ryan M. Bannen, Huiyan Jin, Mark Rowe, Hanying Li, Richard S. Pinapati, Adam J. Cartwright, John C. Tan, Jigar Patel Edward C. Keystone, Katherine A. Siminovitch

Background: Autoantibodies against citrullinated proteins are found in 64–89% of rheumatoid arthritis (RA) patients, with 88–99% specificity. This study was undertaken to create an unbiased, comprehensive profile of serum antibodies against the human proteome, including the citrullinome and the homocitrullinome, in RA patients, using a high‐density peptide array.

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