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Design of a novel nucleus-targeted NLS-KALA-SA nanocarrier to delivery poorly water-soluble anti-tumor drug for lung cancer treatment

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Design of a novel nucleus-targeted NLS-KALA-SA nanocarrier to delivery poorly water-soluble anti-tumor drug for lung cancer treatment

Journal of Pharmaceutical Sciences

Fecha de publicación: January 4, 2021

DOI: https://doi.org/10.1016/j.xphs.2020.12.034

Autores: Chengyun Yan, Weiguo Shi, Jiwei Gu, Robert J. Lee, Yuan Zhang

Background: n this study, we designed a novel nucleus-targeted nanocarrier (NLS-KALA-SA, NKSN) consisting of Kala peptide(KALA), nuclear localization signal(NLS) and stearic acid(SA) using Fmoc solid phase synthesis method. We chose Curcumin(CUR), Paclitaxel(PTX), Ginsenoside compound K(CK) as models of poorly water-soluble antitumor drugs, The drugs loaded NLS-KALA-SA nanoparticles (CUR/NKSN, PTX/NKSN, CK/NKSN) were obained by the dialysis method, their physicochemical properties were determined and antitumor activity were evaluated.

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