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Editorial: Prevention of Rheumatoid Arthritis: Now Is the Time, but How to Proceed?

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Editorial: Prevention of Rheumatoid Arthritis: Now Is the Time, but How to Proceed?

Arthritis & Rheumatology
Volume 69, Issue 5, May 2017, Pages 873–877

Kevin D. Deane, Christopher C. Striebich, V. Michael Holers

Abstract

In rheumatoid arthritis (RA), current clinicalpractice as well as the vast majority of reported studiesfocus on the ability of certain treatments to ameliorateexisting disease activity or to prevent worsening disease inpatients with established and classifiable disease. In addi-tion, however, several trials have tried to address preven-tion of the development of classifiable RA in patientswith undifferentiated arthritis (UA) or joint symptomsdefined as arthralgia and autoantibody positivity withoutinflammatory arthritis, with overall mixed results (1–4). Inparticular, one important contribution to RA preventionis designated Probable Rheumatoid Arthritis: Methotrex-ate versus Placebo Treatment (PROMPT), an innovativeand forward-looking clinical trial designed to stop diseaseprogression from UA to classifiable RA.

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